IMPORTANT MESSAGE REGARDING COVID-19: During this time of great uncertainty, we want to assure you that Diem is taking all necessary measures to protect you, our employees, and our community. As a Michigan-based company, we are now governed by state and federal directives designed to protect the health and safety of us all. At Diem, our on-site staff has been limited and those remaining are outfitted with personal protective equipment. We have instituted strict sanitation protocols, and we are closely monitoring individual wellness to protect you and the entire Diem family.

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How histamine affects your lungs

Histamine and Pulmonary Health Histamine Effect on Lungs

Listen to your lungs – labored breathing can be a sign of histamine activity.

When a foreign substance enters your body, histamine responds. One role of histamine is to promote fluid creation to flush out the invader – such as mucus in the lung’s bronchi.

Unfortunately, histamine’s effects on the lungs can cause symptoms like wheezing and shortness of breath. In fact, histamine release from mast cells plays an important role in asthma as well as environmental allergies.

While the DAO enzyme helps break down histamine in the gut, and thus does not directly impact systemic histamine, those with histamine-mediated health concerns may benefit from taking the enzyme to manage exogenous histamine intake.

What happens when histamine enters lung tissue?

When histamine enters your airway and lungs, it causes mucus production and narrows your airways (bronchoconstriction).

Histamine binds to H1 receptors in the bronchial airway’s mucus membranes. This causes lung tissue to swell and produce excess mucus to help your body remove the allergen.

Histamine also causes trouble for the smooth muscle cells in your lung’s small airways (bronchioles). Normally, these muscle cells control airflow into the lungs by relaxing and contracting. When histamine binds to these cell’s H1 receptors, it increases their calcium ion concentration, which leads to your airways contracting.

Histamine in your lungs causes symptoms like:

  • wheezing
  • cough
  • shortness of breath
  • tight chest

How can you DAO supplementation help?

Those with histamine-mediated health concerns can usually manage their condition through a combination of antihistamine, bronchiodilators and other physician-directed interventions.

Unfortunately, antihistamines and other medications can block the activity of the DAO enzyme in the gut, leading to histamine intolerance, which can further exacerbate symptoms.

Taking a DAO supplement in conjunction with OTC and prescription products can help maintain healthy histamine degradation and defend against the compounding effects of excess histamine intake.