Did you know that your stomach cramps could be the result of histamine activity?
Histamine is well-known for helping the body defend itself from foreign invaders. It also has a very close relationship with your stomach as many foods and stomach conditions affect histamine levels.
Histamine plays an important role in digestion.
Pituitary adenylyl cyclase-activating peptide and gastrin hormones stimulate the release of histamine from the stomach’s enterochromaffin-like cells. When released, histamine binds to H2 receptors on parietal cells in the stomach lining.
The binding triggers stomach acid (gastric acid) secretion which breaks down the food in the stomach. Without histamine, you lose an important factor in the digestive process.
Yes, while the stomach needs histamine for proper digestion, too much of it can cause problems.
High levels of histamine may cause excess stomach acid production which leads to development of Gastroesophageal Reflux Disease (GERD), or acid reflux.
Some foods we eat increase histamine levels by either directly containing histamine (bacon, parmesan cheese, alcohol) or triggering the release of histamine from the small intestines (nuts, chocolate, berries, tomatoes).
Diamine oxidase (DAO) enzyme’s primary function is to break down excess histamine in your body.
Digestive issues (leaky gut, ulcerative colitis) and DAO-blocking foods (i.e. green and black tea) may cause a DAO enzyme deficiency which effectively limits your body’s ability to break down excess histamine (histamine intolerance). This causes: