IMPORTANT MESSAGE REGARDING COVID-19: During this time of great uncertainty, we want to assure you that Diem is taking all necessary measures to protect you, our employees, and our community. As a Michigan-based company, we are now governed by state and federal directives designed to protect the health and safety of us all. At Diem, our on-site staff has been limited and those remaining are outfitted with personal protective equipment. We have instituted strict sanitation protocols, and we are closely monitoring individual wellness to protect you and the entire Diem family.

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Histamine Function in Stomach

Histamine Function in Stomach

Did you know that your stomach cramps could be the result of histamine activity?

Histamine is well-known for helping the body defend itself from foreign invaders. It also has a very close relationship with your stomach as many foods and stomach conditions affect histamine levels.

What does histamine do in the stomach?

Histamine plays an important role in digestion.

Pituitary adenylyl cyclase-activating peptide and gastrin hormones stimulate the release of histamine from the stomach’s enterochromaffin-like cells. When released, histamine binds to H2 receptors on parietal cells in the stomach lining.

The binding triggers stomach acid (gastric acid) secretion which breaks down the food in the stomach. Without histamine, you lose an important factor in the digestive process.

Can histamine harm the digestive system?

Yes, while the stomach needs histamine for proper digestion, too much of it can cause problems.

High levels of histamine may cause excess stomach acid production which leads to development of Gastroesophageal Reflux Disease (GERD), or acid reflux.

What causes histamine levels to increase?

Histamine-rich and Histamine Releasing Foods

Some foods we eat increase histamine levels by either directly containing histamine (bacon, parmesan cheese, alcohol) or triggering the release of histamine from the small intestines (nuts, chocolate, berries, tomatoes).

DAO Enzyme Deficiency

Diamine oxidase (DAO) enzyme’s primary function is to break down excess histamine in your body.

Digestive issues (leaky gut, ulcerative colitis) and DAO-blocking foods (i.e. green and black tea) may cause a DAO enzyme deficiency which effectively limits your body’s ability to break down excess histamine (histamine intolerance). This causes:

  • gas
  • bloating
  • cramping
  • nausea
  • vomiting
  • diarrhea

How to reduce histamine levels in your gut?

  • H2 receptor blockers and proton pump inhibitors can prevent and reduce your stomach acid production.
  • Avoidance of histamine-rich foods and histamine liberators
  • Umbrellux® DAO supplementation. Taking Umbrellux DAO 15-20 minutes before eating provides your body with DAO that it needs to break down excess histamine.